In a small retrospective series, a novel third-space endoscopy technique, per-rectal endoscopic myotomy, was demonstrated to be an effective and safe minimally invasive treatment for short-segment Hirschsprung’s disease with medium-term and long-term efficacy.

Adequate collection and handling of tissue samples during endoscopy is fundamental to pathological diagnosis for the digestive system. This is Part 2 of a two-part ESGE Guideline that provides evidence-based recommendations for optimizing and standardizing tissue collection during gastrointestinal endoscopy, and covers the lower gastrointestinal tract. Part 1 has been published separately and covers the upper gastrointestinal and hepatopancreatobiliary tracts.